TRANSLATIONAL PHYSIOLOGY SLC22A2 is associated with tubular creatinine secretion and bias of estimated GFR in renal transplantation
نویسندگان
چکیده
Anna Reznichenko, Steef J. Sinkeler, Harold Snieder, Jacob van den Born, Martin H. de Borst, Jeffrey Damman, Marcory C. R. F. van Dijk, Harry van Goor, Bouke G. Hepkema, Jan-Luuk Hillebrands, Henri G. D. Leuvenink, Jan Niesing, Stephan J. L. Bakker, Marc Seelen, and Gerjan Navis Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Epidemiology, Unit of Genetic Epidemiology & Bioinformatics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; and Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
منابع مشابه
SLC22A2 is associated with tubular creatinine secretion and bias of estimated GFR in renal transplantation.
Genome-wide association studies reported SLC22A2 variants to be associated with serum creatinine. As SLC22A2 encodes the organic cation transporter 2 (OCT2), the association might be due to an effect on tubular creatinine handling. To test this hypothesis we studied the association of SLC22A2 polymorphisms with phenotypes of net tubular creatinine secretion: fractional creatinine excretion (FEc...
متن کاملبررسی مقایسهای ارزش تشخیصی سیستاتین C و کراتینین سرمی در ارزیابی عملکرد کلیه پیوندی در بیماران گیرنده کلیه در دوران اولیه پس از پیوند
Background &Aim: Early detection of decreasing glomerular filtration rate (GFR) is critical to prevent graft rejection in post-transplantation period. Serum creatinine has several drawbacks as a marker of GFR, so serum cystatin C has been proposed as an alternative GFR marker. Thus, we prospectively evaluated the diagnostic value of cystatin C measurements compared with serum creatinine in t...
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